ASIAN JOURNAL OF PHYSICS

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The theoretical and experimental vibrational study of the anti-HIV d4T (stavudine or Zerit or 3′-deoxy-2,3´-didehydro thymidine) Nucleoside Analogue was carried out. The calculated spectra were scaled by using the linear scaling equation procedure (LSE). The d4T monomer and dimers were simulated by using DFT methods. The IR spectrum was recorded in the solid state in the region 400-4000 cm^-1 and the Raman spectrum was recorded in the region 0-3500 cm^-1. The vibrational bands were analyzed and assigned to different normal modes of vibration by comparison with the scaled values of the different dimer forms. Thus, through this comparison, we were able to confirm that the solid state sample corresponds to dimer V. © Anita Publications. All rights reserved.

Keywords: d4T, Stavudine, anti-HIV, IR spectrum, Raman spectrum, DFT

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